Though relatively few mutations are advantageous, these which might be play an necessary role in evolutionary changes. Like impartial mutations, weakly selected advantageous mutations may be lost as a result of random genetic drift, but strongly selected advantageous mutations are more likely to be mounted. Knowing the DFE of advantageous mutations could lead to increased capability to predict the evolutionary dynamics. Theoretical work on the DFE for advantageous mutations has been carried out by John H. Gillespie and H. They proposed that the distribution for advantageous mutations should be exponential under a wide range of situations, which, in general, has been supported by experimental research, at least for strongly chosen advantageous mutations.
In this experiment it was shown that the general DFE is bimodal, with a cluster of neutral mutations, and a broad distribution of deleterious mutations. The impact of a mutation on protein sequence relies upon partly on where … Read MoreRead More »