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If many mutations accumulate in a somatic cell, they might result in problems such because the uncontrolled cell division observed in most cancers. If a mutation takes place in germ cells, the mutation might be handed on to the following era, as within the case of hemophilia and xeroderma pigmentosa.

However, the transcriptome additionally carries all the genomic information of a cell’s transcribed genome, along with RNA-particular mutations or edits. RNA-seq has been used to establish germline DNA variants , and recently, single-cell (sc) RNA-seq was used to name DNA somatic mutations in the pancreas of a number of individuals . In humans, somatic mutations play a key function in senescence and tumorigenesis .

Mutations also can happen as the results of exposure to environmental components corresponding to smoking, sunlight and radiation. Often cells can acknowledge any probably mutation-causing damage and restore it before … Read More

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