For instance, the Sabin vaccine strains of poliovirus had been developed by rising polioviruses in monkey kidney cells. Mutation and selection produced variant polioviruses that had been adapted for efficient replication in these cells. Some of the mutations in these variants affected the genes coding for the poliovirus coat proteins in such a way as to supply mutants unable to connect to human neural cells however still able to infect human intestinal cells.
Infection of human intestinal cells does not produce paralytic disease but does induce immunity. Poliovirus vaccine strains 1 and a pair of have a number of mutations within the coat proteins and are very stable. The sort 3 vaccine pressure is much less steady and is subject to back-mutations (reversions) that restore neural virulence. This vaccine strain therefore causes paralytic disease in a single out of each a number of million vaccinated people. Despite the possibility of … Read MoreRead More »